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    J Biol Chem. 1999 Feb 12;274(7):4202-6.

    Why superoxide imposes an aromatic amino acid auxotrophy on Escherichia coli. The transketolase connection.

    Benov L, Fridovich I.

    Source

    Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA.

    Abstract

    The lack of superoxide dismutase and the consequent elevation of [O2-] imposes, on Escherichia coli, auxotrophies for branched chain, sulfur-containing, and aromatic amino acids. The former two classes of auxotrophies have already been explained, whereas the third is explained herein. Thus O2- is shown to interfere with the production of erythrose-4-phosphate, which is essential for the first step of the aromatic biosynthetic pathway. It does so by oxidizing the 1, 2-dihydroxyethyl thiamine pyrophosphate intermediate of transketolase and inactivating this enzyme.

    PMID:
    9933617
    [PubMed - indexed for MEDLINE]
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