Neurogenetics. 1998 Dec;2(1):34-42.

Refined mapping and characterization of the recessive familial amyotrophic lateral sclerosis locus (ALS2) on chromosome 2q33.

Hosler BA, Sapp PC, Berger R, O'Neill G, Bejaoui K, Hamida MB, Hentati F, Chin W, McKenna-Yasek D, Haines JL, Patterson D, Horvitz HR, Brown RH Jr, Day CB.

Source

Laboratory for Neuromuscular Research, Neurology Service, Massachusetts General Hospital, MGH-East, Building 149, 13th Street, Charlestown, MA 02129, USA.

Abstract

Amyotrophic lateral sclerosis (ALS) is a progressive degenerative neuromuscular disease that shows familial, autosomal dominant inheritance in 10%-15% of cases. Previous genetic analysis of one large family linked a recessive form of familial ALS (FALS-AR type 3) to the chromosome 2q33-35 region. Using additional polymorphic markers, we have narrowed the size of the linked region to approximately 1.7 cM by linkage and haplotype analysis. We have also established a yeast artificial chromosome contig across the locus that covers an approximate physical distance of 3 million bases. Based on this contig, genes and expressed sequences that map near the 2q33 region have been examined to determine whether they are located within this ALS2 candidate locus. Five identified genes and 34 expressed sequence tags map within the region defined by crossover analysis and merit further consideration as candidate genes for this disease.

PMID:: 9933298; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Genetic Markers

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Medical

ALS2 Gene - Genetics Home Reference

Supplemental Content

Save items

Related citations in PubMed

A yeast artificial chromosome-based physical map of the juvenile amyotrophic lateral sclerosis (ALS2) critical region on human chromosome 2q33-q34. [Genomics. 1999]
A yeast artificial chromosome-based physical map of the juvenile amyotrophic lateral sclerosis (ALS2) critical region on human chromosome 2q33-q34.
Hadano S, Nichol K, Brinkman RR, Nasir J, Martindale D, Koop BF, Nicholson DW, Scherer SW, Ikeda JE, Hayden MR. Genomics. 1999 Jan 1; 55(1):106-12.
Linkage of recessive familial amyotrophic lateral sclerosis to chromosome 2q33-q35. [Nat Genet. 1994]
Linkage of recessive familial amyotrophic lateral sclerosis to chromosome 2q33-q35.
Hentati A, Bejaoui K, Pericak-Vance MA, Hentati F, Speer MC, Hung WY, Figlewicz DA, Haines J, Rimmler J, Ben Hamida C. Nat Genet. 1994 Jul; 7(3):425-8.
Linkage of a commoner form of recessive amyotrophic lateral sclerosis to chromosome 15q15-q22 markers. [Neurogenetics. 1998]
Linkage of a commoner form of recessive amyotrophic lateral sclerosis to chromosome 15q15-q22 markers.
Hentati A, Ouahchi K, Pericak-Vance MA, Nijhawan D, Ahmad A, Yang Y, Rimmler J, Hung W, Schlotter B, Ahmed A, et al. Neurogenetics. 1998 Dec; 2(1):55-60.
Review [Juvenile and adult forms of spinal muscular atrophies]. [Neurologia. 1996]
Review [Juvenile and adult forms of spinal muscular atrophies].
Pou A. Neurologia. 1996 Dec; 11 Suppl 5:43-57.
Review Integrating maps of chromosome 16. [Curr Opin Genet Dev. 1993]
Review Integrating maps of chromosome 16.
Mulley JC, Sutherland GR. Curr Opin Genet Dev. 1993 Jun; 3(3):425-31.

See reviews... See all...

Cited by 1 PubMed Central article

Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin. [Mol Brain. 2009]
Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin.
Lai C, Xie C, Shim H, Chandran J, Howell BW, Cai H. Mol Brain. 2009 Jul 24; 2:23. Epub 2009 Jul 24.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Refined mapping and characterization of the recessive familial amyotrophic later...
Refined mapping and characterization of the recessive familial amyotrophic lateral sclerosis locus (ALS2) on chromosome 2q33.
Neurogenetics. 1998 Dec ;2(1):34-42.

PubMed
Population biology, evolution, and infectious disease: convergence and synthesis...
Population biology, evolution, and infectious disease: convergence and synthesis.
Science. 1999 Feb 5 ;283(5403):806-9.

PubMed
Boswellic acid acetate induces differentiation and apoptosis in leukemia cell li...
Boswellic acid acetate induces differentiation and apoptosis in leukemia cell lines.
Leuk Res. 1999 Jan ;23(1):43-50.

PubMed
Apolipoprotein E-epsilon4 genotype predicts a poor outcome in survivors of traum...
Apolipoprotein E-epsilon4 genotype predicts a poor outcome in survivors of traumatic brain injury.
Neurology. 1999 Jan 15 ;52(2):244-8.

PubMed
Pre-verbal communication.
Pre-verbal communication.
J Child Psychol Psychiatry. 1976 Oct ;17(4):351-3.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: