Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Am J Clin Pathol. 1999 Feb;111(2):202-6.

Intravascular hemolysis secondary to ABO incompatible platelet products. An underrecognized transfusion reaction.

Author information

  • 1Department of Pathology, Creighton University Medical Center at Saint Joseph Hospital, Omaha, Nebraska 68131, USA.

Abstract

Transfusion of ABO-incompatible platelets to a cardiac surgery patients resulted in acute intravascular hemolysis complicated by ventricular tachycardia. Nine similar cases with significant morbidity or mortality have been reported in similar settings. Five fatalities caused by transfusion of ABO-incompatible platelet products have been reported to the US Food and Drug Administration during the last 4 years. Non-group O patients, particularly those with small plasma volumes, receiving multiple non-group specific platelets in a short time are at risk for intravascular hemolysis caused by passively infused anti-A1 or anti-B. To prevent intravascular hemolysis in such at-risk patients, the indications for platelet transfusion must be continually assessed. If transfusion of ABO-incompatible platelet products is necessary, consideration should be given to minimizing the accompanying plasma via further concentration of the platelets or by saline washing of platelet products.

PMID:
9930141
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk