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    Eur Arch Psychiatry Clin Neurosci. 1998;248(6):296-300.

    Antidepressant-associated maniform states in acute treatment of patients with bipolar-I depression.

    Bottlender R, Rudolf D, Strauss A, Möller HJ.

    Source

    Psychiatrische Klinik der Ludwig-Maximilians-Universität, Munich, Germany. bottlend@psy.med.uni-muechen.de

    Abstract

    Medical records of 158 patients with bipolar depression were analysed for the incidence of a switch from depression to maniform states (mania and hypomania). Relation to psychopharmacological treatment was investigated. Thirty-nine (25%) patients of the total sample had switched to a maniform state during the treatment period in the hospital. Among that group the phenomenon occurred in 23 patients (15%) as a hypomania and in 16 patients (10%) as a mania. Patients with a switch were significantly more often treated with tricyclic antidepressants (TCA) than patients without switch (79.5% vs 51.3%). Mood stabilising medication might reduce the risk for switching, especially in patients treated with TCA; however, it seems not totally sufficient, since 59% of the switched patients received mood stabilisers. The switch phenomenon was not associated with sociodemographic or clinical data.

    PMID:
    9928908
    [PubMed - indexed for MEDLINE]

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