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Br J Psychiatry. 1998 Dec;173:494-500.

Age at onset and outcome in schizophrenia are related to the degree of familial loading.

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  • 1Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland. jaana.suvisaari@kt1.fi

Abstract

BACKGROUND:

Recent research suggests that high familial loading is associated with early onset of schizophrenia. Results concerning outcome have been controversial.

METHOD:

We assessed the relationship between familial loading, age at onset and outcome in all Finnish patients with schizophrenia born between 1950 and 1969. Patients and their first-degree relatives were identified using nationwide registers. Familial loading scores were calculated for schizophrenia and for combined psychotic disorders, and patients were accordingly classified into three groups: high (n = 761), intermediate (n = 14,247), and low familial loading (n = 725). Linear mixed models and the Cox proportional hazard model were used in the analyses.

RESULTS:

Onset was earliest, hospitalisation longest and risk of retirement in receipt of a disability pension highest in the group with high familial loading, with opposite extremes found in the group with low familial loading.

CONCLUSIONS:

High familial loading for schizophrenia is associated with early onset and poor outcome of schizophrenia.

PMID:
9926078
[PubMed - indexed for MEDLINE]
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