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5-Chloro-N-(4-methoxy-3-piperazin-1-yl- phenyl)-3-methyl-2-benzothiophenesulfon- amide (SB-271046): a potent, selective, and orally bioavailable 5-HT6 receptor antagonist.
Bromidge SM,
Brown AM,
Clarke SE,
Dodgson K,
Gager T,
Grassam HL,
Jeffrey PM,
Joiner GF,
King FD,
Middlemiss DN,
Moss SF,
Newman H,
Riley G,
Routledge C,
Wyman P.
Departments of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, England, UK.
PMID: 9925723 [PubMed - indexed for MEDLINE]
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Cited by 5 PubMed Central articles
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Efficacy of selective 5-HT6 receptor ligands determined by monitoring 5-HT6 receptor-mediated cAMP signaling pathways.
Romero G, Sánchez E, Pujol M, Pérez P, Codony X, Holenz J, Buschmann H, Pauwels PJ.
Br J Pharmacol. 2006 Aug; 148(8):1133-43. Epub 2006 Jul 24.
[Br J Pharmacol. 2006]
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Chronic 5-HT6 receptor modulation by E-6837 induces hypophagia and sustained weight loss in diet-induced obese rats.
Fisas A, Codony X, Romero G, Dordal A, Giraldo J, Mercé R, Holenz J, Vrang N, Sørensen RV, Heal D, et al.
Br J Pharmacol. 2006 Aug; 148(7):973-83. Epub 2006 Jun 19.
[Br J Pharmacol. 2006]
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Characterization of SB-271046: a potent, selective and orally active 5-HT(6) receptor antagonist.
Routledge C, Bromidge SM, Moss SF, Price GW, Hirst W, Newman H, Riley G, Gager T, Stean T, Upton N, et al.
Br J Pharmacol. 2000 Aug; 130(7):1606-12.
[Br J Pharmacol. 2000]
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