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BMJ. 1999 Jan 30;318(7179):285-8.

Nicotine nasal spray with nicotine patch for smoking cessation: randomised trial with six year follow up.

Author information

  • 1Reykjavik Health Care Centre, Baronstigur 47, 101 Reykjavik and National University Hospital, Iceland. blondal@hr.is

Erratum in

  • BMJ 1999 Mar 20;318(7186):764.

Abstract

OBJECTIVE:

To evaluate the efficacy of using a nicotine patch for 5 months with a nicotine nasal spray for 1 year.

DESIGN:

Placebo controlled, double blind trial.

SETTING:

Reykjavik health centre.

SUBJECTS:

237 smokers aged 22-66 years living in or around Reykjavik.

INTERVENTIONS:

Nicotine patch for 5 months with nicotine nasal spray for 1 year (n=118) or nicotine patch with placebo spray (n=119). Treatment with patches included 15 mg of nicotine for 3 months, 10 mg for the fourth month, and 5 mg for the fifth month, whereas nicotine in the nasal spray was available for up to 1 year. Both groups received supportive treatment.

MAIN OUTCOME MEASURE:

Sustained abstinence from smoking.

RESULTS:

Sustained abstinence rates for the patch and nasal spray group and patch only group were 51% v 35% after 6 weeks (odds ratio 1.97, 95% confidence interval 1.17% to 3.32; P=0.011(chi2), 37% v 25% after 3 months (1.76, 1.01 to 3.08; P=0.045), 31% v 16% after 6 months (2.40, 1.27 to 4.50; P=0.005), 27% v 11% after 12 months (3.03, 1.50 to 6.14; P=0.001), and 16% v 9% after 6 years (2.09, 0.93 to 4.72; P=0.08) [corrected].

CONCLUSIONS:

Short and long term abstinence rates show that the combination of using a nicotine patch for 5 months with a nicotine nasal spray for 1 year is a more effective method of stopping smoking than using a patch only. The low percentage of participants using the nasal spray at 1 year, and the few relapses during the second year, suggest that it is not cost effective to use a nasal spray for longer than 7 months after stopping a patch.

Comment in

PMID:
9924052
[PubMed - indexed for MEDLINE]
PMCID:
PMC27708
Free PMC Article
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