Stat Med. 1998 Dec 30;17(24):2815-34.

Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints.

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MRC Cancer Trials Office, Cambridge, U.K.

Erratum in

Stat Med. 2004 Jun 15;23(11):1817.

Abstract

Meta-analyses aim to provide a full and comprehensive summary of related studies which have addressed a similar question. When the studies involve time to event (survival-type) data the most appropriate statistics to use are the log hazard ratio and its variance. However, these are not always explicitly presented for each study. In this paper a number of methods of extracting estimates of these statistics in a variety of situations are presented. Use of these methods should improve the efficiency and reliability of meta-analyses of the published literature with survival-type endpoints.

PMID:: 9921604; [PubMed - indexed for MEDLINE]

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