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Science. 1999 Jan 22;283(5401):534-7.

Turning brain into blood: a hematopoietic fate adopted by adult neural stem cells in vivo.

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  • 1NeuroSpheres Limited, 3330 Hospital Drive Northwest, Calgary, AB, Canada T2N 4N1.

Abstract

Stem cells are found in various organs where they participate in tissue homeostasis by replacing differentiated cells lost to physiological turnover or injury. An investigation was performed to determine whether stem cells are restricted to produce specific cell types, namely, those from the tissue in which they reside. After transplantation into irradiated hosts, genetically labeled neural stem cells were found to produce a variety of blood cell types including myeloid and lymphoid cells as well as early hematopoietic cells. Thus, neural stem cells appear to have a wider differentiation potential than previously thought.

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PMID:
9915700
[PubMed - indexed for MEDLINE]
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