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J Chromatogr A. 1998 Dec 11;827(2):295-310.

Structural characteristics of low-molecular-mass displacers for cation-exchange chromatography. II. Role of the stationary phase.

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  • 1Department of Chemical Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.


The relative efficacy of a variety of low-molecular-mass displacers was examined on three different stationary phase materials. Several homologous series of displacer molecules were evaluated on these ion-exchange resins using a displacer ranking plot based on the steric mass action model. The results demonstrate that while aromaticity and hydrophobicity can play a significant role in the affinity of displacer molecules on polymethacrylate based and hydrophilized polystyrene-divinylbenzene based materials, this effect is much less pronounced on an agarose based resin. The work presented in this paper demonstrates that different structural features of low-molecular-mass displacers can dominate their affinity on various stationary phase materials employed and provides rules of thumb for the design of high affinity, low-molecular-mass displacers for a variety of commercial cation-exchange materials.

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