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Curr Opin Struct Biol. 1998 Dec;8(6):686-94.

Glutamine PRPP amidotransferase: snapshots of an enzyme in action.

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  • 1Department of Biological Sciences Purdue University West Lafayette IN 47907-1392 USA. smithj@bragg.bio.purdue.edu


Recent studies of glutamine PRPP amidotransferase have provided a new understanding of the function and mechanism of this rather complicated enzyme that may be a paradigm for other complex enzymes. New insights have been gained into the mechanisms of catalysis in the active sites of the two half-reactions, catalytic coupling, allosteric control by feedback inhibitors and the channeling of reaction and metabolic intermediates.

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