Curr Opin Chem Biol. 1998 Dec;2(6):675-9.

Hydrophobic core packing and protein design.

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Department of Molecular and Cell Biology 229 Stanley Hall University of California at Berkeley Berkeley CA 94720 USA.

Abstract

Over the past few years, we have witnessed exciting advances in protein design. Several groups have reported success in the design of hydrophobic cores, and the principles developed in these studies have been recently applied to the full sequence design of a small protein motif and the design of a catalytically active metal center. These successes suggest that designing large, functional proteins in computero is more feasible than ever before.

PMID:: 9914192; [PubMed - indexed for MEDLINE]

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