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Curr Opin Cell Biol. 1998 Dec;10(6):716-20.

Recent progress in identifying genes regulating hematopoietic stem cell function and fate.

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  • 1Blood and Marrow Transplantation Program Markey Cancer Center University of Kentucky Medical Center 800 Rose Street Room CC405 Lexington KY 40536 USA. cjordan@pop.uky.edu


Significant advances in the use of genetic and molecular biology strategies have recently begun to identify genes that have a major impact on the determination, commitment and developmental potential of hematopoietic stem cells. Using a variety of experimental strategies, genes such as SCL, GATA-2, HoxB4, Flk-2, c-mpl, dlk, and others have been implicated as important regulators of stem cell growth. In addition, genetic mapping has identified several loci that correlate strongly with stem cell numbers and proliferation.

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