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University of Colorado School of Medicine, Denver, USA.
The safety and efficacy of the clonidine patch are contingent on the integrity of the transdermal system and the condition of the dermal surface to which it is applied. This article presents the first 2 case reports in the literature of unintentional overdose in pediatric patients with attention-deficit/hyperactivity disorder treated with transdermal clonidine. Appropriate precautions and patient education can help limit toxicity from the clonidine patch in children and adolescents.
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