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Annu Rev Microbiol. 1998;52:491-532.

The HIV-1 Rev protein.

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  • 1Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia 19104-6148, USA.


The nuclear export of intron-containing HIV-1 RNA is critically dependent on the activity of Rev, a virally encoded sequence-specific RNA-binding protein. Rev shuttles between the nucleus and the cytoplasm and harbors both a nuclear localization signal and a nuclear export signal. These essential peptide motifs have now been shown to function by accessing cellular signal-mediated pathways for nuclear import and nuclear export. HIV-1 Rev therefore represents an excellent system with which to study aspects of transport across the nuclear envelope.

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