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EMBO J. 1999 Jan 15;18(2):297-305.

The structure of a PKD domain from polycystin-1: implications for polycystic kidney disease.

Author information

  • 1MRC Centre for Protein Engineering, Lensfield Road, Cambridge CB2 1EW. mb10031@cus.cam.ac.uk

Abstract

Most cases of autosomal dominant polycystic kidney disease (ADPKD) are the result of mutations in the PKD1 gene. The PKD1 gene codes for a large cell-surface glycoprotein, polycystin-1, of unknown function, which, based on its predicted domain structure, may be involved in protein-protein and protein-carbohydrate interactions. Approximately 30% of polycystin-1 consists of 16 copies of a novel protein module called the PKD domain. Here we show that this domain has a beta-sandwich fold. Although this fold is common to a number of cell-surface modules, the PKD domain represents a distinct protein family. The tenth PKD domain of human and Fugu polycystin-1 show extensive conservation of surface residues suggesting that this region could be a ligand-binding site. This structure will allow the likely effects of missense mutations in a large part of the PKD1 gene to be determined.

PMID:
9889186
[PubMed - indexed for MEDLINE]
PMCID:
PMC1171124
Free PMC Article
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