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1: Chem Biol. 1999 Jan;6(1):R3-7.Click here to read Links

Structure-activity relationship homology (SARAH): a conceptual framework for drug discovery in the genomic era.

Frye SV.

Division of Chemistry Glaxo Wellcome Inc., 3.4134 5 Moore Drive Research Triangle Park NC 27709 USA. svf3511@glaxowellcome.com

Extension of the traditional pharmacological approach of protein target classification to whole target systems has the potential to relate elements of protein sequence to the structure-activity relationship (SAR) of small molecules that can modulate protein action. Grouping potential drug discovery targets into families based on the relatedness of their SAR provides a means to translate the information from genome-sequencing efforts into knowledge that will aid in the discovery of drugs.

PMID: 9889153 [PubMed - indexed for MEDLINE]