In conclusion, OPAT is a cost-effective, quality-controlled alternative setting for treating patients with HIV. The program provides a desirable situation for the patient, physician, and nurse. Continuity of care provided by the health care team in the physician's office is a unique situation that can meet the treatment modalities necessary to care for the HIV patient with dignity and pride. In short, OPAT offers an attractive alternative to long-term hospitalization for a variety of HIV-related infections. Such therapy is rapidly becoming a standard of treatment that provides both cost savings and efficacious medical care to patients with HIV-related complications.