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    Mol Cell. 1998 Dec;2(6):709-18.

    The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation.

    Visintin R, Craig K, Hwang ES, Prinz S, Tyers M, Amon A.

    Source

    Whitehead Institute for Biomedical Research, Cambridge Center, Massachusetts 02142, USA.

    Abstract

    Exit from mitosis requires the inactivation of mitotic cyclin-dependent kinases (CDKs) by an unknown mechanism. We show that the Cdc14 phosphatase triggers mitotic exit by three parallel mechanisms, each of which inhibits Cdk activity. Cdc14 dephosphorylates Sic1, a Cdk inhibitor, and Swi5, a transcription factor for SIC1, and induces degradation of mitotic cyclins, likely by dephosphorylating the activator of mitotic cyclin degradation, Cdh1/Hct1. Feedback between these pathways may lead to precipitous collapse of mitotic CDK activity and help coordinate exit from mitosis.

    PMID:
    9885559
    [PubMed - indexed for MEDLINE]

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