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    Neuron. 1998 Dec;21(6):1465-75.

    Synaptic vesicle size and number are regulated by a clathrin adaptor protein required for endocytosis.

    Zhang B, Koh YH, Beckstead RB, Budnik V, Ganetzky B, Bellen HJ.

    Howard Hughes Medical Institute, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA. bxz@bcm.tmc.edu

    Clathrin-mediated endocytosis is thought to involve the activity of the clathrin adaptor protein AP180. However, the role of this protein in endocytosis in vivo remains unknown. Here, we show that a mutation that eliminates an AP180 homolog (LAP) in Drosophila severely impairs the efficiency of synaptic vesicle endocytosis and alters the normal localization of clathrin in nerve terminals. Most importantly, the size of both synaptic vesicles and quanta is significantly increased in lap mutants. These results provide novel insights into the molecular mechanism of endocytosis and reveal a role for AP180 in regulating vesicle size through a clathrin-dependent reassembly process.

    PMID: 9883738 [PubMed - indexed for MEDLINE]

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