Genomics. 1998 Dec 15;54(3):569-74.

cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12.

Rozycka M, Lu YJ, Brown RA, Lau MR, Shipley JM, Fry MJ.

Source

The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, United Kingdom.

Abstract

Phosphoinositide (PI) 3-kinases have been shown to have critical roles in signaling pathways that regulate proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. We have previously used reverse-transcription polymerase chain reaction methods to identify novel PI 3-kinase isoforms in normal human breast and in lymph nodes containing metastatic breast cancer. Here we report the cDNA cloning of a Class II PI 3-kinase found in normal breast tissue. This gene (PIK3C2G) encodes the third distinct protein of the human Class II PI 3-kinase family, PI3K-C2gamma. PIK3C2G was mapped to chromosome 12 at 12p12 by fluorescence in situ hybridization.

PMID:: 9878262; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Secondary Source ID

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

Phosphatidylinositol 3-Kinases

Secondary Source ID

GENBANK/AJ000008

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Cited by 3 PubMed Central articles

Inhibition of class II phosphoinositide 3-kinase gamma expression by p185(Bcr-Abl) contributes to impaired chemotaxis and aberrant homing of leukemic cells. [Leuk Lymphoma. 2010]
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Yu W, Sun X, Tang H, Tao Y, Dai Z. Leuk Lymphoma. 2010 Jun; 51(6):1098-107.
Topographical expression of class IA and class II phosphoinositide 3-kinase enzymes in normal human tissues is consistent with a role in differentiation. [BMC Clin Pathol. 2003]
Topographical expression of class IA and class II phosphoinositide 3-kinase enzymes in normal human tissues is consistent with a role in differentiation.
El Sheikh SS, Domin J, Tomtitchong P, Abel P, Stamp G, Lalani EN. BMC Clin Pathol. 2003 Oct 16; 3(1):4. Epub 2003 Oct 16.
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