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1: Alzheimer Dis Assoc Disord. 1998 Dec;12(4):384-6.Links

Intracellular receptors for activated C-kinase in the postmortem human brain: no alteration in Alzheimer disease.

Shimohama S, Kamiya S, Taniguchi T, Kimura J.

Department of Neurology, Faculty of Medicine, Kyoto University, Japan.

Previous studies have identified a 36-kDa protein that has the properties of an intracellular receptor for the activated C-kinase (RACK1). In the present investigation we quantified levels of RACK1 protein in brains from patients with Alzheimer disease (AD) and age-matched controls. Western analysis using a specific antibody showed that the protein levels for RACK1 were not significantly different in AD brains than in controls, indicating that RACK1 is preserved in AD.

PMID: 9876970 [PubMed - indexed for MEDLINE]