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Bioorg Med Chem Lett. 1998 Nov 17;8(22):3281-6.

Restricting the flexibility of crosslinked, interfacial peptide inhibitors of HIV-1 protease.

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  • 1Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.


Interfacial peptides of HIV-1 protease were crosslinked with varying length alkyl-chains containing either a single cis or trans double bond, or a triple bond to remove degrees of freedom within the tethers. The synthesis of these compounds and their effects on the activity of HIV-1 protease are described.

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