Bioorg Med Chem Lett. 1998 Oct 6;8(19):2699-704.

Tropane-based amino acids for peptide structure-function studies: inhibitors of platelet aggregation.

Thompson PE, Steer DL, Aguilar MI, Hearn MT.

Source

Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia. Phil.Thompson@boxhill.med.monash.edu.au

Abstract

Novel tropane (azabicycloheptane) and azabicyclohexane containing amino acids have been prepared and incorporated into analogues of reported inhibitors of platelet aggregation. The influence of these central constraints upon biological activity suggest their utility in peptide structure function studies.

PMID:: 9873606; [PubMed - indexed for MEDLINE]

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