Abstract
A new class of borneol esters that might be considered as biological analogs of paclitaxel regarding their action on microtubules has been found. By structure-activity optimizations, compounds stabilizing microtubules much better than paclitaxel while showing a remarkably reduced cytotoxic activity were obtained. This dissoziation will open completely new therapeutic areas.
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology
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Biopolymers
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Camphanes / chemical synthesis*
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Camphanes / chemistry
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Camphanes / pharmacology
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Drug Screening Assays, Antitumor
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Humans
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Microtubules / drug effects
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Microtubules / metabolism*
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Models, Molecular
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Paclitaxel / chemistry
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Paclitaxel / pharmacology
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Structure-Activity Relationship
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Antineoplastic Agents, Phytogenic
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Biopolymers
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Camphanes
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isoborneol
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Paclitaxel