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Bioorg Med Chem Lett. 1998 Jan 6;8(1):93-6.

Novel antiproliferative falcarindiol furanocoumarin ethers from the root of Angelica japonica.

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  • 1Faculty of Pharmaceutical Sciences, Fukuoka University, Japan.


Four novel antiproliferative furanocoumarin ethers of falcarindiol, named japoangelols A (8.5), B (7.2), C (7.4), and D (8.4), were isolated from the root of Angelica japonica together with panaxynol (0.3), falcarindiol (3.2), (9Z)-1,9-heptadecadiene-4,6-diyne-3,8,11-triol (2.2), and 8-acetoxyfalcarinol (3.2). Structures were established from the spectroscopic evidence, and the inhibitory activities (ED50, microgram/ml, shown in the parentheses) were evaluated using the MTT assay.

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