Amino Acids. 1998;15(3):263-9.

Free D- and L-amino acids in ventricular cerebrospinal fluid from Alzheimer and normal subjects.

Fisher G, Lorenzo N, Abe H, Fujita E, Frey WH, Emory C, Di Fiore MM, D' Aniello A.

Source

Department of Chemistry, Barry University, Miami Shores, Florida, USA.

Abstract

Free D-Ser, D-Asp and total D-amino acids were significantly higher (p < 0.05) in Alzheimer (AD) ventricular CSF than in normal CSF. There was no significant difference in the total L-amino acids between AD and normal CSF, but L-Gln and L-His were significantly higher (p < 0.05) in AD-CSF. The higher concentrations of these D- and L-amino acids in AD ventricular CSF could reflect the degenerative process that occurs in Alzheimer's brain since ventricular CSF is the repository of amino acids from the brain.

PMID:: 9871505; [PubMed - indexed for MEDLINE]

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