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Emerg Infect Dis. 1998 Oct-Dec;4(4):631-4.

Mycobacterium canettii, the smooth variant of M. tuberculosis, isolated from a Swiss patient exposed in Africa.

Author information

  • 1Swiss National Center for Mycobacteria, Department of Medical Microbiology, University of Zurich, Switzerland. pfyffer@immv.unizh.ch

Abstract

An exceptionally smooth and glossy morphotype of Mycobacterium tuberculosis complex was isolated from a 56-year-old Swiss patient with mesenteric tuberculosis. Direct 16S rRNA sequence analysis of the hypervariable signature gene regions revealed a 100% homology to the specific M. tuberculosis complex sequence. Spoligotyping and restriction fragment length polymorphism analyses using the insertion sequences IS6110 and IS1081 and the polymorphic GC-rich sequence as additional genetic markers identified the isolate as the novel taxon M. canettii. Like a Somali child with a similar case, this patient probably contracted the infection in Africa, which raises questions about the geographic distribution of M. canettii.

PMID:
9866740
[PubMed - indexed for MEDLINE]
PMCID:
PMC2640258
Free PMC Article
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