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Mol Biol Evol. 1998 Dec;15(12):1647-57.

Estimating the rate of evolution of the rate of molecular evolution.

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  • 1Statistics Department, North Carolina State University, Raleigh 27695-8203, USA.


A simple model for the evolution of the rate of molecular evolution is presented. With a Bayesian approach, this model can serve as the basis for estimating dates of important evolutionary events even in the absence of the assumption of constant rates among evolutionary lineages. The method can be used in conjunction with any of the widely used models for nucleotide substitution or amino acid replacement. It is illustrated by analyzing a data set of rbcL protein sequences.

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