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Chem Biol. 1998 Dec;5(12):R323-33.

Radically novel prostaglandins in animals and plants: the isoprostanes.

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  • Institute of Pharmacy, University of Munich, Karlstrasse 29 D-80333, Munich, Germany. Martin.Mueller@lrz.uni-muenchen.de


Animal prostaglandins and plant jasmonates are well-known enzymatically formed cyclopentanoic lipids that have regulatory functions and serve as inducible mediators of host defense reactions. A novel group of prostaglandin-like compounds, the isoprostanes, generated in animals and plants by a nonenzymatic, free radical-catalyzed process, are now suspected to be mediators of oxidant injury in vivo.

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