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1: Acta Haematol. 1998 Dec;100(3):151-5.Click here to read Links

Immunoblastic lymphadenopathy-like T cell lymphoma evolving into a massive plasma cell proliferation with biclonal paraproteinemia.

Higuchi T, Tada J, Mori H, Niikura H, Omine M, Kishimoto K, Tate G, Mitsuya T.

Division of Hematology, Internal Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.

We present a case of immunoblastic lymphadenopathy-like T cell lymphoma (IBL-T) who subsequently developed a massive proliferation of plasma cells. At diagnosis of IBL-T, the patient had polyclonal hypergammaglobulinemia and subsequently, while on chemotherapy, developed paraproteinemia with biclonal peaks and the IBL-T lesion was replaced with a massive proliferation of CD38-positive plasma cells. The evolution was not likely to be attributed to a new neoplastic proliferation of B cells. It appeared that two B cell clones possibly had a growth advantage among the polyclonal B cells due to a depletion of suppressor T cells or to a disturbance in the immune system.

PMID: 9858793 [PubMed - indexed for MEDLINE]

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