Science. 1998 Dec 18;282(5397):2258-61.

Interleukin-13: central mediator of allergic asthma.

Wills-Karp M, Luyimbazi J, Xu X, Schofield B, Neben TY, Karp CL, Donaldson DD.

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Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA. mkarp@welchlink.welch.jhu.edu

Abstract

The worldwide incidence, morbidity, and mortality of allergic asthma are increasing. The pathophysiological features of allergic asthma are thought to result from the aberrant expansion of CD4(+) T cells producing the type 2 cytokines interleukin-4 (IL-4) and IL-5, although a necessary role for these cytokines in allergic asthma has not been demonstrable. The type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma. IL-13 induces the pathophysiological features of asthma in a manner that is independent of immunoglobulin E and eosinophils. Thus, IL-13 is critical to allergen-induced asthma but operates through mechanisms other than those that are classically implicated in allergic responses.

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Interleukin-13's key role in asthma shown. [Science. 1998]
Interleukin-13's key role in asthma shown.Vogel G. Science. 1998 Dec 18; 282(5397):2168.
Science. 1999 May 28;284(5419):1431.

PMID:: 9856949; [PubMed - indexed for MEDLINE]

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