The authors assessed occupationally significant visual functions in anisometropy varying in type and degree. Disorders of occupationally significant visual functions depend reliably on anisometropy degree. Correction of anisometropy with recovered vision and binocular functions restores all parameters of night and color vision. Optic and operative correction of anisometropy could be used for rehabilitation of railway machine operators with long length of service. The article provides recommendations to use intraocular lenses for artiphakia in railway machine operators.