Format

Send to:

Choose Destination
See comment in PubMed Commons below
Can J Surg. 1998 Dec;41(6):455-8.

Lipoblastoma and liposarcoma in children: an analysis of 9 cases and a review of the literature.

Author information

  • 1Department of Surgery, University of British Columbia, British Columbia's Children's Hospital, Vancouver. miller@duke,usask.ca

Abstract

OBJECTIVES:

To review the experience at a children's hospital of lipoblastoma and liposarcoma and to identify any factors that would differentiate one type of tumour from the other.

DESIGN:

A retrospective case series.

SETTING:

British Columbia's Children's Hospital a tertiary-care pediatric centre.

PATIENTS:

All patients with a pathological diagnosis of lipoblastoma and liposarcoma recorded over 12 years.

MAIN OUTCOME MEASURES:

The frequency of lipoblastoma and liposarcoma, identified from biopsy specimens of pediatric adipose tumours. The clinical, pathological and cytogenetic variables between lipoblastoma and liposarcoma.

RESULTS:

One hundred and forty-nine adipose tumours were recorded. Seven (4.7%) were lipoblastomas and 2 (1.3%) were liposarcomas. All tumours presented as asymptomatic, slow-growing, soft-tissue masses. The children with lipoblastoma tended to be younger, but 29% were over 3 years of age. The liposarcoma patients were aged 9 and 14 years. One liposarcoma was of myxoid type and the other was a round cell variant. Karyotypes were reported for 1 lipoblastoma and 1 liposarcoma. The myxoid liposarcoma karyotype was 46,XY,t(12;16)(q13;p11), and the lipoblastoma was reported as 46,XY,der(8)?t(8q;?),+mar.

CONCLUSIONS:

Lipoblastoma is an unusual childhood neoplasm and liposarcoma is very rare in children. Both tumours may present in a similar fashion, and differentiating them histologically can be difficult. Age cannot be relied upon to accurately predict their behaviour. The tumour karyotype is very helpful in differentiating these neoplasms.

PMID:
9854536
[PubMed - indexed for MEDLINE]
PMCID:
PMC3949803
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for The Canadian Medical Association Icon for PubMed Central
    Loading ...
    Write to the Help Desk