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Trends Cell Biol. 1998 Nov;8(11):442-6.

Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction.

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  • 1Program in Molecular Medicine, University of Massachusetts Medical School, Worcester 01615, USA.


Phosphoinositide 3-kinases are a family of lipid kinases that phosphorylate the 3' position of the inositol ring on phosphatidylinositol and higher-phosphorylated polyphosphoinositides. The multiplicity of cellular functions influenced by the activity of these enzymes has captured the attention of researchers working on two important fields of cell biology--signal transduction and membrane traffic. This review discusses how the recent identification of proteins that interact directly with 3'-polyphosphoinositides has revealed novel potential interconnections between these fundamental cellular processes.

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