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    Mol Genet Metab. 1998 Nov;65(3):187-90.

    A human succinate-ubiquinone oxidoreductase CII-3 subunit gene ending in a polymorphic dinucleotide repeat is located within the sulfonylurea receptor (SUR) gene.

    Wohllk N, Thomas PM, Huang E, Cote GJ.

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    Section of Endocrinology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, 77030, USA.

    Abstract

    We report the cloning of two variant genes encoding the CII-3 subunit of succinate-ubiquinone oxidoreductase complex II. One gene is located within intron 10 of the human sulfonylurea receptor gene. The 3' boundary of this gene ends in a polymorphic dinucleotide repeat. The second gene CII-3b is expressed at a low level and contains a 102-bp internal deletion compared to CII-3 cDNA. These genes should prove valuable in the characterization of Complex II disorders.

    Copyright 1998 Academic Press.

    PMID:
    9851882
    [PubMed - indexed for MEDLINE]

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