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J Virol. 1999 Jan;73(1):754-9.

Human herpesvirus 6 latently infects early bone marrow progenitors in vivo.

Author information

  • 1Section of Hematology, Department of Medical Sciences, University of Modena, Modena, Italy.

Abstract

We have studied the in vivo tropism of human herpesvirus 6 (HHV-6) for hemopoietic cells in patients with latent HHV-6 infection. Having used a variety of cell purification, molecular, cytogenetic, and immunocytochemical procedures, we report the first evidence that HHV-6 latently infects early bone marrow progenitor cells and that HHV-6 may be transmitted longitudinally to cells which differentiate along the committed pathways.

PMID:
9847383
[PubMed - indexed for MEDLINE]
PMCID:
PMC103884
Free PMC Article
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