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J Virol. 1999 Jan;73(1):362-7.

Dynamics of human immunodeficiency virus type 1 replication in vertically infected infants.

Author information

  • 1Department of Pediatrics, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Boston, Massachusetts, USA. katherine.luzuriaga@ummed.edu

Abstract

Plasma human immunodeficiency virus type 1 (HIV-1) turnover and kinetics were studied in children aged 15 days to 2 years following the initiation of a triple antiretroviral drug regimen consisting of zidovudine, lamivudine, and nevirapine. HIV-1 turnover was at least as rapid as that previously described in adults; turnover rates were more rapid in infants and children aged 3 months to 2 years than in infants less than 3 months of age. These data confirm the central role of HIV-1 replication in the pathogenesis of vertical HIV-1 infection and reinforce the importance of early, potent combination therapies for the long-term control of HIV-1 replication.

PMID:
9847340
[PubMed - indexed for MEDLINE]
PMCID:
PMC103841
Free PMC Article
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