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    Immunity. 1998 Nov;9(5):627-35.

    Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development.

    Ranger AM, Oukka M, Rengarajan J, Glimcher LH.

    Source

    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115-6017, USA.

    Abstract

    Nuclear factor of activated T cells (NFAT) is a critical regulator of early gene transcription in response to TCR-mediated signals. Here, we show that mice lacking both NFATp and NFAT4 develop a profound lymphoproliferative disorder likely due to a lowered threshold for TCR signaling coupled with increased resistance to apoptosis secondary to defective FasL expression. NFAT mutant mice also have allergic blepharitis, interstitial pneumonitis, and a 10(3) to 10(4) fold increase in serum IgG1 and IgE levels, secondary to a dramatic and selective increase in Th2 cytokines. This phenotype may be ascribed to unopposed occupancy of the IL-4 promoter by NFATc. Our data demonstrate that lymphoid homeostasis and Th2 activation require a critical balance among NFAT family members.

    PMID:
    9846484
    [PubMed - indexed for MEDLINE]

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