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Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14897-902.

Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation.

Author information

  • 1Laboratory of Immunobiology, Dana-Farber Cancer Institute, and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

Abstract

An intracellular protein termed CD2 binding protein 2 (CD2BP2), which binds to a site containing two PPPGHR segments within the cytoplasmic region of CD2, was identified. Mutagenesis and NMR analysis demonstrated that the CD2 binding region of CD2BP2 includes a 17-aa motif (GPY[orF]xxxxM[orV]xxWxxx GYF), also found in several yeast and Caenorhabditis elegans proteins of unknown function. In Jurkat T cells, over-expression of the isolated CD2BP2 domain binding to CD2 enhances the production of interleukin 2 on crosslinking of CD2 but not the T cell receptor. Hence, a proline-binding module distinct from SH3 and WW domains regulates protein-protein interactions.

PMID:
9843987
[PubMed - indexed for MEDLINE]
PMCID:
PMC24547
Free PMC Article

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