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    Am J Public Health. 1998 Dec;88(12):1801-6.

    Declining seroprevalence in a very large HIV epidemic: injecting drug users in New York City, 1991 to 1996.

    Source

    Chemical Dependency Institute, Beth Israel Medical Center, New York, NY 10003, USA. dcdesjarla@aol.com

    Abstract

    OBJECTIVES:

    This study assessed recent trends in HIV seroprevalence among injecting drug users in New York City.

    METHODS:

    We analyzed temporal trends in HIV seroprevalence from 1991 through 1996 in 5 studies of injecting drug users recruited from a detoxification program, a methadone maintenance program, research storefronts in the Lower East Side and Harlem areas, and a citywide network of sexually transmitted disease clinics. A total of 11,334 serum samples were tested.

    RESULTS:

    From 1991 through 1996, HIV seroprevalence declined substantially among subjects in all 5 studies: from 53% to 36% in the detoxification program, from 45% to 29% in the methadone program, from 44% to 22% at the Lower East Side storefront, from 48% to 21% at the Harlem storefront, and from 30% to 21% in the sexually transmitted disease clinics (all P < .002 by chi 2 tests for trend).

    CONCLUSIONS:

    The reductions in HIV seroprevalence seen among injecting drug users in New York City from 1991 through 1996 indicate a new phase in this large HIV epidemic. Potential explanatory factors include the loss of HIV-seropositive individuals through disability and death and lower rates of risk behavior leading to low HIV incidence.

    PMID:
    9842377
    [PubMed - indexed for MEDLINE]
    PMCID: PMC1509056
    Free PMC Article

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