Format

Send to:

Choose Destination
See comment in PubMed Commons below
Int J Biochem Cell Biol. 1998 Nov;30(11):1153-7.

The Brn-3a transcription factor.

Author information

  • 1Department of Molecular Pathology, Windeyer Institute of Medical Sciences, University College London, UK.

Abstract

Brn-3a is a member of the POU family of transcription factors which is expressed predominantly in neuronal cells. It exists in two forms, with the long form containing 84 amino acids at the N-terminus which are lacking in the short form. The N-terminal domain unique to the long form allows it to induce expression of the Bcl-2 gene and protect neuronal cells from apoptosis whereas the C-terminal POU domain common to both forms is sufficient for activating a number of other neuronally expressed genes and stimulating neuronal process outgrowth. These effects of Brn-3a suggest that manipulation of its expression by pharmacological or gene therapy procedures may be of benefit in human neurological diseases.

PMID:
9839440
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk