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Brain Res. 1998 Dec 14;814(1-2):218-21.

Absence of antinociceptive tolerance to improgan, a cimetidine analog, in rats.

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  • 1Department of Pharmacology and Neuroscience, Albany Medical College, Albany, NY, USA.mbannoura@ccgateway.amc.edu

Abstract

Improgan, an analog of the histamine receptor antagonist cimetidine, produces highly effective analgesia following intraventricular injection. The present study examined changes in the antinociceptive effects of improgan following once daily intraventricular injections. Improgan (100-150 microg) produced near maximal antinociception 10 and 30 min after daily administration on all 4 test days, whereas comparable morphine treatments (50 microg) induced considerable tolerance. Thus, improgan produced highly effective analgesia without the development of tolerance.

Copyright 1998 Elsevier Science B.V.

PMID:
9838126
[PubMed - indexed for MEDLINE]
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