Send to:

Choose Destination
See comment in PubMed Commons below
Brain Res. 1998 Dec 14;814(1-2):218-21.

Absence of antinociceptive tolerance to improgan, a cimetidine analog, in rats.

Author information

  • 1Department of Pharmacology and Neuroscience, Albany Medical College, Albany, NY,


Improgan, an analog of the histamine receptor antagonist cimetidine, produces highly effective analgesia following intraventricular injection. The present study examined changes in the antinociceptive effects of improgan following once daily intraventricular injections. Improgan (100-150 microg) produced near maximal antinociception 10 and 30 min after daily administration on all 4 test days, whereas comparable morphine treatments (50 microg) induced considerable tolerance. Thus, improgan produced highly effective analgesia without the development of tolerance.

Copyright 1998 Elsevier Science B.V.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk