KCNQ2 and KCNQ3 potassium channel subunits: molecu...[Science. 1998]

SearchDatabase nameforSearch term

Advanced Search (beta)

Your browser version may not work well with NCBI's Web applications. More information here...

Display Show

All: 1

Review: 0

Click to change filter selection through MyNCBI.

1: Science. 1998 Dec 4;282(5395):1890-3. Links

Comment in:: Science. 1998 Dec 4;282(5395):1794-5.

KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel.

Wang HS, Pan Z, Shi W, Brown BS, Wymore RS, Cohen IS, Dixon JE, McKinnon D.

Institute of Molecular Cardiology, Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, NY 11794, USA.

The M-current regulates the subthreshold electrical excitability of many neurons, determining their firing properties and responsiveness to synaptic input. To date, however, the genes that encode subunits of this important channel have not been identified. The biophysical properties, sensitivity to pharmacological blockade, and expression pattern of the KCNQ2 and KCNQ3 potassium channels were determined. It is concluded that both these subunits contribute to the native M-current.

PMID: 9836639 [PubMed - indexed for MEDLINE]

Reconstitution of muscarinic modulation of the KCNQ2/KCNQ3 K(+) channels that underlie the neuronal M current. [J Neurosci. 2000]
Molecular correlates of the M-current in cultured rat hippocampal neurons. [J Physiol. 2002]
Stoichiometry of expressed KCNQ2/KCNQ3 potassium channels and subunit composition of native ganglionic M channels deduced from block by tetraethylammonium. [J Neurosci. 2003]
ReviewKCNQ2/KCNQ3 K+ channels and the molecular pathogenesis of epilepsy: implications for therapy. [Trends Neurosci. 2000]
ReviewKCNQ potassium channels: physiology, pathophysiology, and pharmacology. [Pharmacol Ther. 2001]

Patient Drug Information

Potassium (Glu-K®, K+ 10®, K+ 8®, ...) Potassium is essential for the proper functioning of the heart, kidneys, muscles, nerves, and digestive system. Usually the food you eat supplies all of the potassium you need. However, certain diseases (e.g., kidney dis...

» read more ...

Display Show

KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel.

Related Articles