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Chem Biol. 1998 Nov;5(11):R291-301.

Chemical basis for alkali cation selectivity in potassium-channel proteins.

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  • Department of Pharmacology Department of Cellular and Molecular Physiology Yale University School of Medicine New Haven Connecticut 06520-8066 USA. edward.moczydlowski@yale.edu.


The determination of the crystal structure of a K+-selective channel protein from Streptomyces lividans reveals how the rapid movement of K+ across membranes is catalyzed by a large family of pore-forming proteins. Many features of the structure mirror hypotheses, predictions and models of K+ channels developed over the past four decades of functional analysis.

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