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J Bacteriol. 1998 Dec;180(23):6424-8.

Role of the C terminus of FtsK in Escherichia coli chromosome segregation.

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  • 1Department of Microbiology and Molecular Genetics, University of Texas Medical School, Houston, Texas 77030, USA.


FtsK is essential for Escherichia coli cell division. We report that cells lacking the C terminus of FtsK are defective in chromosome segregation as well as septation, often exhibiting asymmetrically positioned nucleoids and large anucleate regions. Combining the corresponding truncated ftsK gene with a mukB null mutation resulted in a synthetic lethal phenotype. When the truncated ftsK was combined with a minCDE deletion, chains of minicells were generated, many of which contained DNA. These results suggest that the C terminus of FtsK has an important role in chromosome partitioning.

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