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Gene structure and chromosomal localization of the human P2X7 receptor.
Geneva Biomedical Research Institute, Switzerland. GB15879@GGR.CO.UK
The genomic organization for the human P2X7 receptor gene was determined to comprise 13 exons. Alignment of the exon-intron junctions with those for the rat P2X2 gene demonstrated a precise conservation of the boundaries for the first 10 introns. The human P2X7 receptor gene was localized by in situ hybridization to chromosome 12q24. Radiation hybrid mapping indicated that this is within 130 kb of the gene for the homologous P2X4 receptor.
PMID: 9826911 [PubMed - indexed for MEDLINE]
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Cited by 5 PubMed Central articles
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Genetics of the P2X7 receptor and human disease.
Fuller SJ, Stokes L, Skarratt KK, Gu BJ, Wiley JS.
Purinergic Signal. 2009 Jun; 5(2):257-62. Epub 2009 Mar 25.
[Purinergic Signal. 2009]
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Effects of toxic cellular stresses and divalent cations on the human P2X7 cell death receptor.
Dutot M, Liang H, Pauloin T, Brignole-Baudouin F, Baudouin C, Warnet JM, Rat P.
Mol Vis. 2008 May 19; 14:889-97. Epub 2008 May 19.
[Mol Vis. 2008]
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Standardized method to minimize variability in a functional P2X(7) flow cytometric assay for a multi-center clinical trial.
Korpi-Steiner NL, Sheerar D, Puffer EB, Urben C, Boyd J, Guadarrama A, Schell K, Denlinger LC.
Cytometry B Clin Cytom. 2008 Sep; 74(5):319-29.
[Cytometry B Clin Cytom. 2008]
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