Biophys J. 1998 Dec;75(6):3179-83.

Temperature transitions of protein properties in human red blood cells.

Artmann GM, Kelemen C, Porst D, Büldt G, Chien S.

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Department of Cell Biophysics, Aachen University of Applied Sciences, Ginsterweg 1, D-52428 Jülich, Germany. artmann@fh-aachen.de

Abstract

Human red blood cells (RBC) undergo a sudden change from blocking to passing through 1.3 +/- 0.2-micrometer micropipettes at a transition temperature (Tc) of 36.4 degrees C. For resealed RBC ghosts this transition occurs at 28.3 degrees C (Tg). These findings are attributed to an elastomeric transition of hemoglobin from being gel-like to a fluid and to an elastomeric transition of membrane proteins such as spectrin. Spectrin shows a uniform distribution along the aspirated RBC tongue above Tg in contrast to the linear gradient below Tg.

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