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Biochem Biophys Res Commun. 1998 Nov 18;252(2):433-9.

Analysis of a human cDNA containing a tissue-specific alternatively spliced LIM domain.

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  • 1Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, Bethesda, Maryland, USA.


A unique clone, isolated from a human pancreatic cDNA library, was sequenced and characterized. Northern blot analysis showed that the gene is active in a number of fetal and adult tissues, and immunoblots showed expression in nuclear and cytosolic cell fractions. The gene corresponding to the clone was localized to chromosome 13 by human/rodent somatic cell hybrid panels. The largest open reading frame contains a LIM domain, and the deduced peptide from the open reading frame appears to have the characteristics of a LIM-only protein, designated LMO7. RT-PCR and genomic sequence analyses indicate that expression of this gene product is subject to tissue-specific modulation by elimination of the LIM domain by alternative splicing in neural tissues.

Copyright 1998 Academic Press.

[PubMed - indexed for MEDLINE]
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