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    Biochem Biophys Res Commun. 1998 Nov 18;252(2):378-82.

    Cloning, chromosal mapping, and tissue expression of the gene encoding the human Eph-family kinase ligand ephrin-A2.

    Aasheim HC, Pedeutour F, Grosgeorge J, Logtenberg T.

    Source

    Department of Immunology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, 0310, Norway. h.c.asheim_labmed.uio.no

    Abstract

    The Eph-related receptor tyrosine kinases constitute a large family of receptors with most members displaying specific expression patterns in the developing embryo. Ligands for Eph receptor tyrosine kinases, recently renamed ephrins, comprise a family of at least 8 membrane-bound members that display promiscuous binding to Eph receptors. Here we report the characterization of a human cDNA clone with high homology to the gene encoding the murine ephrin-A2 ligand. The human gene encodes a single 2.4-kb mRNA with a restricted and developmentally-regulated tissue distribution pattern. In the fetus, ephrin-A2 mRNA is expressed in brain and intestine, whereas in the adult, high levels of ephrin-A2 mRNA are detectable in lung and intestine. Using PCR-based screening of genomic DNA from human x rodent hybrid cell lines, the gene encoding ephrin-A2 (EFNA2) was assigned to chromosome 19. Fluorescence in situ hybridization to metaphase chromosome preparations refined this localization to band p13.3.

    Copyright 1998 Academic Press.

    PMID:
    9826538
    [PubMed - indexed for MEDLINE]

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